The Coulter Principle (1954-1955)
While under contract to the United States Navy in the late 1940s, Wallace H. Coulter developed a technology for counting and sizing particles using impedance measurements. The technology was principally developed to count blood cells quickly by measuring the changes in electrical conductance as cells suspended in a conductive fluid passed through a small orifice. Presently, over 98% of automated cell counters incorporate this technology, which is referred to as the Coulter Principle. In the past seventy-five years, the technology has also been used to characterize thousands of different industrial particulate materials.
Beckman Coulter instrument systems which utilize this principle are called COULTER COUNTER instruments. Drugs, pigments, fillers, toners, foods, abrasives, explosives, clay, minerals, construction materials, coating materials, metals, filter materials, and many other sample types have all been analyzed using the Coulter Principle. This method can be used to measure any particulate material that can be suspended in an electrolyte solution. Particles as small as 0.4 µm and as large as 1600 µm in diameter can routinely be measured. Over 8,000 references to the uses of this technology have been documented.
In a COULTER COUNTER instrument, a tube with a small aperture on the wall is immersed into a beaker that contains particles suspended in a low-concentration electrolyte. Two electrodes, one inside the aperture tube and one outside the tube but inside the beaker, are placed and a current path is provided by the electrolyte when an electric field is applied (Figure 1). The impedance between the electrodes is then measured. The aperture creates what is called a "sensing zone". Particles in low concentration, suspended in the electrolyte, can be counted by passing them through the aperture. As a particle passes through the aperture, a volume of electrolyte equivalent to the immersed volume of the particle is displaced from the sensing zone. This causes a short-term change in the impedance across the aperture. This change can be measured as a voltage pulse or a current pulse. The pulse height is proportional to the volume of the sensed particle. If constant particle density is assumed, the pulse height is also proportional to the particle mass. This technology is also referred to as aperture technology.
Using count- and pulse-height analyzer circuits, the number and volume of each particle passing through the aperture can be measured. If the volume of liquid passing through the aperture can be precisely controlled and measured, the sample concentration can also be determined. In modern COULTER COUNTER instruments, such as the Multisizer™ 3 and 4, particle counter and sizing instruments, pulses are digitized and saved with several key parameters that describe each pulse such as pulse height, pulse width, time stamp, pulse area, etc. These parameters enable the instrument to better discriminate between noise and real pulses as well as between normal and distorted pulses due to various reasons when particles pass through the aperture. Saved pulses can be used to monitor sample changes over the measurement time period should pulses be arranged in time sequence. In practice, particle volume is often represented in terms of equivalent spherical diameter. The measured particle volume (or size) can be then used to obtain particle size distribution.
With counting and sizing rates of up to 10,000 particles per second, it takes less than one minute to perform a typical measurement with a COULTER COUNTER instrument. The accuracy of size measurements can be better than 1%. Aperture size typically ranges from 20-2000 µm. Each aperture can be used to measure particles within a size range of 2 to 80% of nominal diameter. Therefore, an overall particle size-range of 0.4-1600 µm is feasible. However, the ability of the technology to analyze particles is limited to those particles that can be suitably suspended in an electrolyte solution. The upper limit therefore may be 500 µm for sand but only 75 µm for tungsten carbide particles. Moreover, the lower size limit is restricted by electronic noise generated mainly within the aperture itself. The selection of the most suitable aperture size is dependent upon the particles to be measured. If the sample to be measured is composed of particles largely within a 30:1 diameter size range, the most suitable aperture can be chosen. For example, a 30 µm aperture can measure particles from about 0.6 to 18 µm in diameter. A 140 µm aperture can measure particles from about 2.8 to 84 µm. If the particles to be measured cover a wider range than a single aperture can measure, two or more apertures must be used and the test results can be overlapped to provide a complete particle size distribution.
Highest Resolution for Particle Size Analysis
During the Coulter Principle measurement, as a particle passes through the sensing zone when the liquid is drawn from the container, a volume of the electrolyte equivalent to the immersed volume of the particle is displaced from the sensing zone. This causes a short-term change in the resistance across the aperture. This resistance change can be measured either as a voltage or current pulse. By measuring the number of pulses and their amplitudes, one can obtain information about the number of particles and the volume of each individual particle.
The number of pulses detected during measurement is the number of particles measured, and the amplitude of the pulse is proportional to the volume of the particle. Because this is a single-particle measurement process, it yields the highest resolution that any particle characterization technique can achieve. The particle diameter can be determined at the resolution of voltage or current measurement which can be very accurately using current electronics technology. The distribution amplitude can be determined to the accuracy of a single particle.
The advantages of such high resolution are multiple with the most obvious being the capability to display details of a particle size distribution. In a particle size distribution measurement, typically each distribution, whether displayed cumulatively or differentially, is composed of a few-hundred data points in a pre-set size range. Each data point is called a bin. Since every particle is measured, each bin is a collection of particles in a given size range. Depending on the distribution broadness, the total size range can be reset to a finer division, therefore showing the distribution details (i.e., each bin can be pre-set to cover a smaller size range).
Other advantages include fine differential between two particles and more accurate statistic values calculated from the distribution. The figures below show a sample measured using the Beckman Coulter Multisizer 4 and displayed in different size ranges. The pulse data was resorted into a finer set of bins in the right figure in which more detail of the distribution is displayed.
Digital Pulse Process
In Coulter Principle instrumentation, the change in electric resistance due to passages of particles through the aperture is determined using fast electronic circuitry. Detected signals are instantaneously digitized at a rate of a few-million times per second into digital signals. The digital signal is then recorded for every pulse in the form of pulse parameters (i.e., timing, height, width of pulses, etc.). As most measurements seek to obtain particle counting or size distribution, the recorded pulse height is converted to particle size using the calibration constant and placed into one of the pre-set size bins. Particle size distribution and counting are the cumulative result of all pulses measured. All recorded pulse parameters are still available for purposes other than standard, full-range particle size distribution. These parameters can be subtracted or sorted (i.e., reprocessed differently based on specific applications). For example, if an operator seeks to have a zoom-in size distribution showing every detail of the distribution, then a narrower size range can be selected and all pulses can be sorted and placed into the new set of finer bins. Another example is found when pulse heights (or sizes) are sorted in a time sequence (for samples of narrow size-distribution) t monitor sample change during measurement. Still another example is using one plot pulse height as a function of pulse width to find information of particle shape.
As a particle passes through the aperture, it creates a resistance. The bigger the particle, the more the resistance, the greater the voltage. Each voltage spike is directly proportional to the size of the cell. Today every modern hematology analyzer depends in some way on the Coulter Principle.
Coulter Counter Model F
A method was devised for using the model F Coulter Counter for counting goat erythrocytes, which are smaller and more numerous than those of humans. Blood samples were taken from 25 goats, and the cells were counted using 100- and 70-micron aperature tubes. A visual count also was made of a portion of each sample. The results were analyzed statistically to determine which aperture would produce the most accurate and reproducible results when compared with the manual counts. It was found that counts obtained with the 100-micron aperature tube were not significantly different from the manual counts.
This technology found commercial success in the medical industry where it revolutionized the science of hematology. Red blood cells, white blood cells and platelets make up the majority of the formed elements in the blood. When whole anticoagulated human blood is diluted with isotonic saline, the Coulter principle can be applied to count and size the various cells that make up whole blood. The first commercial application of the Coulter principle to hematology came in 1954 with the release of the Coulter Counter Model A (developed by Wallace and brother Joseph R. Coulter.
Within a decade, literally every hospital laboratory in the United States had Coulter Counter, and today every modern hematology analyzer depends in some way on the Coulter Principle.
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- Miniaturized Enzo Life Sciences HDAC1 Fluor de Lys Assays Using an Echo Liquid Handler Integrated in an Access Laboratory Workstation
- Miniaturized Enzymatic Assays with Glycerol
- Miniaturized EPIgeneous HTRF Assays Using the Echo Liquid Handler
- Miniaturized Gene Expression in as Little as 250 nL
- Miniaturized Genotyping Reactions Using the Echo Liquid Handler
- Miniaturized Sequencing Workflows for Microbiome and Metagenomic Studies
- Mixed Mode Sorting on the CytoFLEX SRT
- Mode of operation of optical sensors for dissolved oxygen and pH value
- Modular DNA Assembly of PIK3CA Using Acoustic Liquid Transfer in Nanoliter Volumes
- Multi-Wavelength Analytical Ultracentrifugation of Human Serum Albumin complexed with Porphyrin
- Nanoliter Scale DNA Assembly Utilizing the NEBuilder HiFi Cloning Kit with the Echo 525 Liquid Handler
- Low-pH profiling in µL-scale to optimize protein production in H. polymorpha using the BioLector
- Optimized NGS Library Preparation with Acoustic Liquid Handling
- Spectral Flow Cytometry: A Detailed Scientific Overview
- Performance of the Valita Aggregation Pure assay vs HPLC-SEC
- Phototrophic cultivation of Chlorella vulgaris in the BioLector XT microbioreactor
- Plate Deposition Speed Comparison of Astrios and CytoFLEX SRT Cell Sorters
- Precision measurement of adipocyte size with Multisizer4e
- Principles of Continuous Flow Centrifugation
- Flow Cytometric Approach to Probiotic Cell Counting and Analysis
- Protocols for use of SuperNova v428 conjugated antibodies in a variety of flow cytometry applications
- Purifying High Quality Exosomes using Ultracentrifugation
- Quality Control of Anti-Blocking Powder Particle Size
- A Rapid Flow Cytometry Data Analysis Workflow Using Machine Learning- Assisted Analysis to Facilitate Identifying Treatment- Induced Changes
- Rapid Rabbit IgG Quantification using the Valita Titer Assay
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Screening yeast extract to improve biomass production in acetic acid bacteria starter culture
- Full Automation of the SISCAPA® Workflow using a Biomek NXP Laboratory Automation Workstation
- Leveraging the Vi-CELL MetaFLEX for Monitoring Cell Metabolic Activity
- Unveiling the Hidden Signals: Overcoming Autofluorescence in Spectral Flow Cytometry Analysis
- Sorting Rare E-SLAM Hematopoietic Stem Cells Using CytoFLEX SRT and Subsequent Culture
- Unlocking Insights: The Vital Role of Unmixing Algorithms in Spectral Flow Cytometry
- Specification Comparison of Vi–CELL XR and Vi–CELL BLU
- A Standardized, Automated Approach For Exosome Isolation And Characterization Using Beckman Coulter Instrumentation
- Streamlined Synthetic Biology with Acoustic Liquid Handling
- Switching from Oil Testing to Water and back using the HIAC 8011+ and HIAC PODS+
- SWOFF The unrecognized yet indispensable sibling of FMO
- The scattered light signal: Calibration of biomass
- Using k-Factor to Compare Rotor Efficiency
- Utilization of the MicroClime Environmental Lid to Reduce Edge Effects in a Cell-based Proliferation Assay
- Vaporized Hydrogen Peroxide Decontamination of Vi–CELL BLU Instrument
- Vesicle Flow Cytometry with the CytoFLEX
- Automating the Valita Titer IgG Quantification Assay on a Biomek i-Series Liquid Handling System
- Variability Analysis of the Vi-CELL BLU Cell Viability Analyzer against 3 Automated Cell Counting Devices and the Manual Method
- Vi-CELL BLU Regulatory Compliance - 21 CFR Part 11
- Viral Vector Purification with Ultracentrifugation
- Analytical Ultracentrifugation (AUC) for Characterization of Lipid Nanoparticles (LNPs): A Comprehensive Review
- Leveraging Analytical Ultracentrifugation for Comprehensive Characterization of Lipid Nanoparticles in Drug Delivery Systems
- Whole Genome Sequencing of Microbial Communities for Scaling Microbiome and Metagenomic Studies Using the Echo 525 Liquid Handler and CosmosID
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Brochures, Flyers and Data Sheets
- Access Single Robot System for Synthetic Biology Workflows
- Automated Solutions for Cell Line Development
- Automated Solutions for ELISA
- Echo Acoustic Liquid Handling for Synthetic Biology
- HIAC 8011+ Liquid Particle Counting Systems
- HIAC 9703+ Sub-Visible Particulate Testing
- LS 13 320 XR - Laser Diffraction Particle Size Analyzer
- Download the Valita Titer Assay Brochure
-
Case Studies
- Achieving Increased Efficiency and Accuracy in Clinical Testing
- Adenoviral Vectors Preparation
- Algae Biofuel Production
- Antibody and Media Development
- Autophagy
- B Cell Research
- Basic Research on Reproductive Biology
- Cardiovascular Disease Research
- Cell Marker Analysis
- Choosing a Tabletop Centrifuge
- Collagen Disease Treatment
- Contribute To Society By FCM
- Controlling Immune Response
- Creating Therapeutic Agents
- DNA Extraction from FFPE Tissue
- English Safety Seminar
- Equipment Management
- Exosome Purification Separation
- Fast, Cost-Effective and High-Throughput Solutions for DNA Assembly
- Future of Fishing Immune Research
- Hematopoietic Tumor Cells
- High-throughput next-generation DNA sequencing of SARS-CoV-2 enabled by the Echo 525 Liquid Handler
- Hiroshima Genbaku HP Hematopoietic Tumor Testing
- iPS Cell Research
- Leveraging acoustic and tip-based liquid handling to increase throughput of SARS-CoV-2 genome sequencing
- Membrane Protein Purification X Ray Crystallography
- Organelles Simple Fractionation
- Particle Interaction
- Quality evaluation of gene therapy vector
- Retinal Cell Regeneration
- Sedimentary Geology
- Severe Liver Disease Treatment
- Tierra Biosciences reveals major molecular discovery
- Treating Cirrhosis
- University Equipment Management
- Fundamentals of Ultracentrifugal Virus Purification
- Catalogs
- Flyers
-
Interviews
- Background and Current Status of the Introduction of Flow Cytometers
- Bacteriological-measurements-of-soil-bacteria-in-paddy-fields
- Benefits-of-the-coulter-principle-in-the-manufacturing-for-ips-cell-derived-natural-killer-cells
- Central Diagnosis in the Treatment of Childhood Leukemia 1
- Central Diagnosis in the Treatment of Childhood Leukemia 2
- Challenges-in-viability-cell-counting
- Contribution of Cytobank to 1-cell analysis of the cancer microenvironment
- Development of technology for social implementation of synthetic biology
- Flow Cytometry Testing in Hospital Laboratories
- Fundamentals of Ultracentrifugal Virus Purification
- Tumor Suppressor Gene p53 research and DNA Cleanup Process
- Fundamentals of Ultracentrifugal Virus Purification
- Dr Yabui UCF Lecture
-
Posters
- Applications of Ultracentrifugation in Purification and Characterization of Biomolecules
- Automating Genomic DNA Extraction from Whole Blood and Serum with GenFind V3 on the Biomek i7 Hybrid Genomic Workstation
- ABRF 2019: Automated Genomic DNA Extraction from Large Volume Whole Blood
- Automated library preparation for the MCI Advantage Cancer Panel at Miami Cancer Institute utilizing the Beckman Coulter Biomek i5 Span-8 NGS Workstation
- Automating Cell Line Development for Biologics
- Cell-Line Engeneering
- Characterizing the Light-Scatter Sensitivity of the CytoFLEX Flow Cytometer
- AACR 2019: Isolation and Separation of DNA and RNA from a Single Tissue or Cell Culture Sample
- Mastering Cell Counting
- Preparing a CytoFLEX for Nanoscale Flow Cytometry
- A Prototype CytoFLEX for High-Sensitivity, Multiparametric Nanoparticle Analysis
- ABRF 2019: Simultaneous DNA and RNA Extraction from Formalin-Fixed Paraffin Embedded (FFPE) Tissue
- Quantification of AAV Capsid Loading Fractions: A Comparative Study
- Using Standardized Dry Antibody Panels for Flow Cytometry in Response to SARS-CoV2 Infection
- Product Instructions
- Experimental Protocols
-
Whitepapers
- Centrifugation is a complete workflow solution for protein purification and protein aggregation quantification
- AUC Insights - Analysis of Protein-Protein-Interactions by Analytical Ultracentrifugation
- A General Guide to Lipid Nanoparticles
- Analytical Ultracentrifugation: A Versatile and Valuable Technique for Macromolecular Characterization
- Addressing issues in purification and QC of Viral Vectors
- GMP Cleanrooms Classification and Routine Environmental Monitoring
- Purification of Biomolecules by DGUC
- AUC Insights - Assessing the quality of adeno-associated virus gene therapy vectors by sedimentation velocity analysis
- AUC Insights - Sample concentration in the Analytical Ultracentrifuge AUC and the relevance of AUC data for the mass of complexes, aggregation content and association constants
- Analyzing Biological Systems with Flow Cytometry
- Changes to USP <1788> Subvisible Particulate Matter
- Changes to USP <643> Total Organic Carbon
- Characterization of RNAdvance Viral XP RNA Extraction Kit using AccuPlex™ SARS–CoV–2 Reference Material Kit
- CytoFLEX Platform Gain Independent Compensation Enables New Workflows
- CytoFLEX Platform Flow Cytometers with IR Laser Configurations: Considerations for Red Emitting Dyes
- Evaluation of the Analytical Performance of the AQUIOS CL Flow Cytometer in a Multi-Center Study
- Simultaneous Isolation and Parallel Analysis of gDNA and total RNA for Gene Therapy
- Hydraulic Particle Counter Sample Preparation
- Inactivation of COVID–19 Disease Virus SARS–CoV–2 with Beckman Coulter Viral RNA Extraction Lysis Buffers
- Tips for Cell Sorting
- Liquid Biopsy Cancer Biomarkers – Current Status, Future Directions
- MET ONE 3400+ IT Implementation Guide
- Reproducibility in Flow Cytometry
- SuperNova v428: New Bright Polymer Dye for Flow Cytometry
- SuperNova v428: New Bright Polymer Dye for Flow Cytometry
- Japan Document
-
Application Notes
-
Videos
-
Product Videos
- Access Laboratory Workstation Introduction
- Allegra V-15R Features and Benefits
- Allegra V-15R Launch Event
- AQUIOS CL How It Works
- AQUIOS Designer Software Workflow Efficiency
- AQUIOS CL Flow Cytometer Online Presentation
- Automated Positive-Pressure Extraction: Biomek i-Series Integrated Solutions
- BeckmanConnect Privacy and Security Highlights
- BioLector XT Microbioreactor
- BioLector XT Microbioreactor & Biomek i5 Liquid Handler Integration
- Biomek i-Series and Echo Acoustic Liquid Handler Integrated Workstation
- Biomek i Series: Dual Gripping on the i7 Hybrid
- Biomek i Series: Gripper Rotation and Navigation on High-Density Deck
- Biomek i Series: Intrawell Pipetting for Mixing Using 96 Multichannel
- Biomek i Series: Parallel Processing on the i7 Hybrid
- Biomek i Series: Transferring Labware In/Out of an on-deck Automated Thermal Cycler (ATC)
- Biomek i5 for Automating Protein Quantification & Characterization
- Biomek i5 for Automating Screening & Hit Picking
- Biomek i-Series: 6-Column Multichannel Plate Transfer
- Biomek i-Series: 96 Multichannel Selective Tip Pipetting by Row and by Column
- Biomek i-Series: 96 Multichannel Tip Loading
- Biomek i-Series: Large Volume Transfer Using the 96 Multichannel
- CellMek SPS Innovation Keynote
- CellMek SPS Overview
- CellMek SPS Workflow
- Cydem VT Automated Cell Culture System
- CytExpert Compensation Workflow
- Overview of Cytobank Features and Functions
- DxFLEX Flow Cytometer
- Echo Liquid Handler Can Simultaneously Normalize and Pool NGS Library
- Fully Automated Clone Selection: Biomek i-Series Integrated Solutions
- History of Automation
- Inside the DXFLEX Flow Cytometer Photodetectors in Flow Cytometry
- Introducing the QbD1200 TOC Analyzer
- MET ONE 3400+ Series Airborne Particle Counter
- MET ONE 3400+ Series Airborne Particle Counter
- Microtiter plate lid management
- Photodetectors in Flow Cytometry
- QbD1200 Virtual Demo of Calibration
- QbD1200 Virtual Demo of Paperless Reporting
- QbD1200 Virtual Demo of a Measurement Setup
- Reagent Kits for Viral RNA Extraction
- Span-8 1 mL tip loading
- Valita Titer Intro
- VD-016a-flow
- VD-031a-flow
- VD-032a-flow
- VD-033a-flow
- VD-035a-flow
- VD-048a-auto
- VD-057a-flow
- VD-060a-part
- VD-067a-cent
- VD-068a-cent
- VD-081a-auto
- VD-091a-part
- VD-093a-auto
- VD-095a-flow
- VD-098a-part
- VD-123a-cent
- VD-144a-auto
- VD-145a-auto
- VD-146a-auto
- VD-151a-auto
- VD-163a-flow
- VD-168a-flow
- VD-179a-flow
- VD-180a-flow
- VD-186a-flow
- VD-187a-flow
- VD-188a-flow
- VD-189a-flow
- VD-190a-flow
- VD-191a-flow
- VD-192a-flow
- VD-193a-flow
- VD-194a-flow
- VD-195a-flow
- VD-196a-flow
- VD-197a-flow
- VD-199a-auto
- VD-200a-auto
- VD-201a-auto
- VD-202a-auto
- VD-203a-auto
- VD-204a-part
- VD-205a-part
- VD-206a-part
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- VD-220a-part
- VD-221a-part
- VD-222a-part
- VD-237a-auto
- VD-239a-part
- VD-241a-auto
- VD-242a-auto
- VD-250a-cent
- VD-251a-cent
- VD-252a-cent
- VD-253a-cent
- VD-254a-cent
- VD-255a-cent
- VD-256a-cent
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- VD-258a-cent
- VD-259a-cent
- VD-275a-cent
- VD-292a-part
- VD-293a-part
- VD-294a-part
- VD-297a-auto-ruo-ex-2021
- VD-301a-cent
- VD-302a-cent
- VD-303a-cent
- VD-309a-auto
- VD-313a-auto
- Vi-CELL BLU Analyzer Integration with Sartorius Ambr® 250 High Throughput Bioreactor & Ambr ® 15 Cell Culture Systems
- Vi-CELL BLU Sample Flow Animation
- Introducing the Vi-CELL MetaFLEX
- DURA Innovations: A Better Monday
- Advantages of ClearLLab LS
- Allegra General Purpose Centrifuge Line
- Allegra X-15R - Aerosolve Package
- Allegra X-15R Centrifuge Performance
- AQUIOS CL Flow Cytometer Analysis and Reporting
- AQUIOS CL Flow Cytometer Automated and Single Loading
- AQUIOS CL Flow Cytometer Pipeline Sample Processing
- AQUIOS CL Flow Cytometer Sample Preparation
- AQUIOS CL Flow Cytometer Smart Track Reagent Monitoring
- AQUIOS CL Flow Cytometry Workflow Efficiency
- Automate Flow Cytometry Assays
- i-Series Automated Workstations Teaser 1
- Avanti J-26S Performance
- Avanti J-26S Portfolio
- Avanti J-26S Redesign Advantages
- Avanti J-26S Safety and Reliability
- Avanti J-26S Sustainability
- Avanti J-26S User Experience
- Avanti J-26S Versatility
- Avanti JXN High Performance Centrifuge - Bioproduction
- Avanti JXN High Performance Centrifuge -- Manual Run
- Avanti JXN Series High Performance Centrifuge: Introduction
- Avanti JXN Series High Performance Centrifuges in Shared Labs
- Avanti JXN-26 High Performance Centrifuge
- Biomek 4000 Automated Workstation Overview
- Centrifuge Service Installation
- ClearLLab 10C System for Integrated L&L Immunophenotyping
- Offline analysis of CytExpert files using Kaluza Analysis Software
- Bandpass filter light path of the CytoFLEX
- Wavelength Division Multiplexer of the CytoFLEX
- CytoFLEX Lasers and Integrated Optics
- CytoFLEX LX Introduction
- Peristaltic Pump in the CytoFLEX
- CytoFLEX Flow Cytometer Plate Loader Option Overview
- CytoFLEX flow cytometry for the bench (and other fun locales)
- CytoFLEX Flow Cytometer Special Procedure
- DURA Innovation Workflow Comparison
- DURA Innovations Technology and Advantages
- DxFLEX Overview
- Ease of Use Avanti JXN - High Performance Centrifuges
- Gallios Flow Cytometer Overview
- Harvest Line System Liner: How to Use
- Harvest Line System Liner: How to Use
- HIAC 8011+ Digital Exports and Web Server
- HIAC 8011+ Liquid Particle Counter Features
- HIAC 8011 Plus Interchangeable Sensors and Magnetic Stirrer
- HIAC 8011+ Liquid Particle Counter Overview
- HIAC 8011+ Product Demonstration
- HIAC 8011+ Liquid Particle Counter Sample Recipe Setup
- 8011+ Sample Recipe Wizard
- HIAC 8011+ Self-Diagnostic Alerts and Cleaning Routines
- HIAC 8011+ Vacuum and Degas
- HIAC PODS+ Digital Exports
- HIAC PODS+ Filter Cart Mode
- HIAC PODS+ Internal Compressor and Moisture Detector
- HIAC PODS+ Online Mode
- HIAC PODS+ Liquid Particle Counter -- An Overview
- HIAC PODS+ Product Demonstration
- HIAC PODS+ Sample Recipe Wizard
- HIAC PODS+ Self-Diagnostic Alerts and Cleaning Routines
- Introducing the Biomek i-Series Automated Workstation
- Introducing the LS 13 320 XR
- Introduction to AUC - an Analytical Ultracentrifuge
- Introduction to CytoFLEX LX
- i-Series Automated Workstations Teaser 4
- Kaluza Reads FCS Compliant Files: FACSCelesta
- Kaluza Reads FCS Files: FACSVerse Acquisition Data
- Kaluza Software Award
- Kaluza Software Design
- Kaluza Software Launch
- Kaluza Software Parametric Visualization
- Kaluza Software Performance
- LS 13 320 Overview - Particle Characterization
- LS 13 320 XR ADAPT Software
- LS 13 320 XR: X-D Array and PIDS Technology
- Changing the Module in the LS 13 320 XR
- Multisizer 4e Cell Counter and Analyzer -- An Overview
- Searching for the Oldest Centrifuge
- Optima AUC Overview, New Analytical Ultracentrifuge
- Optima MAX Series - Tabletop Ultracentrifuge
- Optima X Series Ultracentrifuges - An Overview
- Optima XE and XPN Ultracentrifuge Performance
- Optima XE and XPN Safety and Reliability
- Optima XE and XPN Ultracentrifuges: A Total System
- The Optimized Path to Pharmaceutical Production
- Results with Tandem Dyes
- The AQUIOS CL Flow Cytometer Advantage
- The History of AUC - An Analytical Ultracentrifuge
- Ultra Harmonic Technology in the Avanti J-15 Centrifuge
- Unboxing Your New CytoFLEX Flow Cytometer
- Vi-CELL BLU Livestream Announcement
- Vi-CELL BLU Product Launch
-
Scientific Videos
- Overview of Density Gradient Equilibrium Analytical Ultracentrifugation (DGE-AUC)
- 3D Imaging of Cancer Spheroids
- A Simplified Approach to Automating ELISA
- Advances in Cellular Automation
- Advances in Synthetic Biology Technologies: Cell-Free Protein Synthesis from Academia to Applied Market
- Automated 3D Cell Culture and Screening by Imaging and Flow Cytometry
- Automated Cell Culture Workflows: Biomek Integrated Solutions
- Automated group testing at scale to enable COVID-19 decision makers - Using Echo for tapestry pooling and high-throughput qPCR setup
- Avalanche Photodiodes in CytoFLEX
- Biomek FXP as a tool for discovery
- CAR-T Cell Therapy: Introduction and Overview
- Cellular Solutions of all Shapes and Sizes
- Centrifuge 101
- Challenging Samples in Cancer Research: Formalin-Fixed Paraffin-Embedded Tissues
- Contract Manufacturing Services
- CRISPR for Immunotherapy: Introduction and Overview
- Custom Design Services for Multi-Color Flow Cytometry
- Cytogenetics Cancer Research
- Digital Pathology Image Analysis for Cancer Research
- DNA and RNA Sequencing Sample Preparation
- DURAClone Technology
- Echo Acoustic Liquid Handling Technology
- ELISA Automation on a Biomek i-Series
- An Overview of Exosome Isolation
- The Principle of Flow Cytometry (FCM)
- Flow Cytometric Analysis of Hematologic Malignancies with ClearLLab LS Tube
- Gene Therapy Workflow from Production to Quality Control
- Automated human stem cell-based phenotypic high-throughput drug screening
- How Automation Helps to Improve your ELISA
- Immunotherapy Introduction and Overview
- New Strategies to Improve Your CE-SDS Results from a Data-Driven Perspective
- New Automation Strategies for Improving Sample Prep for The Analytical Laboratory
- Increasing NGS Sequencing Capacity with High-Throughput Automated TruSeq Stranded mRNA Library Construction
- Industrial Fluid Particle Counter Sample Preparation
- Innovation to Improve Genomic Sample Prep
- Introduction to Automating NGS Workflows
- Introduction to Flow Cytometry
- Multipurpose robotic platform for molecular biology, biophysical, and cellular assays
- NanoGBS - A Miniaturized Procedure for Genotyping By Sequencing Library Preparation
- Automated NEBNext Ultra Directional RNA Library Prep Kit
- Phospho Epitopes Exposure Kit
- Proteome Centric Precision Medicine - Embracing Pathological Diversity
- Evaluation to Implementation with the University of Luxembourg
- Sample Preparation for Biologics Bioanalysis
- Chemogenomics - Screening of Biologically Active Drug Libraries
- Small Talk: Episode 1 - Before You Even Start…
- Small Talk Episode 2 - Harvesting EVs
- Small Talk: Episode 3 - Getting Ready for Your Experiment
- Small Talk Episode 4 - Let's Explore
- Small Talk Episode 5 - The Power of Flow
- Small Talk Q&A
- SPRI Bead Technology Video
- A Streamlined Approach to Automating ELISA
- Cell volume is an important indicator of white blood cell health and therapeutic potential
- Translating Nature into Medicine Using Machine Learning, Metabolomics, and High-Throughput Pharmacology
- Trends in Mass Spectrometry
- Unlocking FFPE Tissues using Illumina NGS Biomek Automated Sample Preparation
- VersaComp Antibody Capture Beads
- Viral Particle Production 101
- Viral Vectors Introduction and Overview
- Workflow Challenges Solved: The Palmer Lab
-
Symposium Videos
- Assessing Proliferation and Cytotxic Potential Using Multicolor Flow Cytometry
- AUC Symposium: Characterization of Gene Therapy Formulations by Analytical Ultracentrifugation
- AUC Symposium - Building Better Things with the Analytical Ultracentrifuge
- AUC Symposium - Lipid Nanoparticles: Paradigm-Shifting Nucleic Acid Therapeutics
- AUC Symposium Panel Discussion - June 2021
- Analytical Ultracentrifuge (AUC) Symposium Series: Multiwavelength Analysis of Proteins (Session 1)
- Analytical Ultracentrifuge (AUC) Symposium Series: Multiwavelength Analysis of Proteins (Session 2)
- Automation of sample preparation for an efficient protein quantification workflow for proteomics
- Covid Symposium Day1, Q&A, Panel Discussion
- Anis Larbi Physiological Aging and Immunological Erosion
- Andrea Cossarizza Recognizing the Immune Response to SARS-CoV-2
- Ryan Brinkman The COVID Cytometry Project
- Q & A Session from Day 2, Viral Particle Detection and Characterization
- Silvana Verdiani New ELISA Kit for Serological Testing for SARS COV-2 Infection
- Miranda Byrne-Steele A Needle in a Haystack Using Immune Repertoire and Single Cell VDJ Sequencing to Identify COVID-specific B-cell Responses
- Marc-Andre Langlois Learnings from Single Particle Analysis of Moloney MLV Insight into its Infectivity, Genome Packaging Efficiency, and Host Marker Acquisition
- Q & A Session from Day 3, Vaccine and Therapy Development
- Jean Boyer Development and Immune Assessment of a DNA Vaccine Against COVID-19
- Bernhard Ellinger Using drug repurposing to identify inhibitors of SARS-CoV-2 cellular toxicity in vitro
- Bruce Patterson Disruption of the CCL5RANTES-CCR5 Pathway 1 Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19
- DKMS Life Science Lab: ultra-high throughput HLA genotyping for stem cell donor recruitment
- Extracellular Vesicles for ‘Liquid Biopsy’ Development in Cancer by Dr. Karla Williams
- Introduction to Mesenchymal Stem Cell DURAClone Dry Reagents
- Miniaturization of metagenomic RNA-seq library prep demonstrates greatly improved productivity and efficiency when utilizing acoustic liquid handling
- Miniaturized Illumina Nextera XT Library Prep using an Integrated Biomek i5 and Echo 525 Liquid Handling Workstation
- Monitoring Signal Transduction Pathways in Human Disease
- Multi-Sizing your Multi-Color Panel
- SynBioBeta 2020 with Beckman Coulter Life Sciences
-
Testimonial Videos
- Allegra V-15R Testimonial by Dr. Martin J. Richer
- AQUIOS CL Flow Cytometer Advantages
- Mobile Lab with AQUIOS - Dr Lillian Hesselink
- Mobile Lab with AQUIOS - Dr Roy Spijkerman
- BeckmanConnect Tohoku University
- Collaborative data analysis platform explained by our expert Herve Luche
- CytoFLEX Testimonial from Dr. Karen Hogg, University of York, United Kingdom
- Discovery in Motion: High-throughput Automation Solutions at Sintef
- Sintef: Why a CRO Chooses to Automate their Lab with Biomek Liquid Handlers
- Using Vertical Rotors and the new VTi 50.1 by Chris Nieder
- Dr. Karla Williams on Analyzing Extracellular Vesicles Using the CytoFLEX
- Reflections on 70 Years of Centrifugation Innovation
- Exosomes Workflow Testimonial with Dr. Vannberg
- Collaboration with the University of York and Dr. Karen Hogg
- Dr. Jurgen Riedl, Clinical Chemist, Albert Schweitzer Hospital Customer Testimonial
- Customer Testimonial: Flow Cytometry Service and Support with Dr. Karen Hogg
- Selecting High Performance Flow Cytometry Reagents with Dr. Karen Hogg
- High Quality Flow Cytometry Reagent Selection Criteria with Dr. Karen Hogg
- A new dimension in simplified AUC analysis - Dr. Borries Demeler
- AQUIOS CL Benefits with Casiana Fernandez-Bango
- AQUIOS CL Size Testimonial with Alexandra Amador
- AQUIOS CL Software Testimonial with Casiana Fernandez-Bango
- AQUIOS CL Training Testimonial with Alexandra Amador
- Sales to Implementation with the University of Luxembourg
- CytoFLEX Cancer Biology Research Testimonial with Leonardo Salmena
- CytoFLEX Capabilities Testimonial with Sarah Schuett
- CytoFLEX Lab Perspective Testimonial with Sarah Schuett
- CytoFLEX S Accelerated Research Testimonial with Brian Phillip
- CytoFLEX S Contest Winner Testimonial with Brian Phillip
- CytoFLEX S Potential Testimonial with Brian Phillip
- CytoFLEX Upgrades Testimonial with Sarah Schuett
- CytoFLEX Value Testimonial with Sarah Schuett
- Kaluza Software Testimonial with Dr. Rob Woestenenk
- Kaluza Software Testimonial with Tim Hutten
- Utilizing the CytoFLEX Testimonial with Leonardo Salmena
-
Training Videos
- CytoFlex operation in Chinese
- AQUIOS CL Flow Cytometer - Advanced Operation Training
- AQUIOS CL Flow Cytometer - Advanced Operation Training in French
- AQUIOS CL Advanced Operation in German
- AQUIOS CL Advanced Operation in Italian
- AQUIOS CL Advanced Operation in Portuguese
- AQUIOS CL Advanced Operation in Russian
- AQUIOS CL Advanced Operation in Spanish
- AQUIOS CL Flow Cytometer - Basic Operation Training
- AQUIOS CL Basic Operation in French
- AQUIOS CL Basic Operation in German
- AQUIOS CL Basic Operation in Italian
- AQUIOS CL Basic Operation in Portuguese
- AQUIOS CL Basic Operation in Russian
- AQUIOS CL Basic Operation in Spanish
-
Tutorial Videos
- 5 Years of high-throughput strain engineering with the Echo: lessons from Zymergen Automation presented by Christopher Bremner, Automation Engineer, Zymergen @SLAS2020
- Characterization of CytoFLEX Gain Settings
- Cytobank Basics
- Cytobank CITRUS
- Cytobank Experiment Manager
- Cytobank FlowSOM
- Cytobank SPADE
- Cytobank viSNE
- Creating an Experiment using CytoFLEX
- Generating a Compensation Matrix using CytoFLEX
- CytoFLEX How to Set Up Violet Side Scatter
- How to Install Rotors on Allegra V-15R
- How to Program ECO Mode on Allegra V-15R
- How to Program Rapid Temp on Allegra V-15R
- How to Register Your Instrument with BeckmanConnect
- How to Set-Up and Run a Program on Allegra V-15R
- Intellifuge Calculator Introduction
- Kaluza Batch Analysis Tutorial with Dr. David Onion
- Kaluza Boolean Gates tutorial with Dr. David Onion
- Kaluza Cell Cycle Analysis Tutorial with Dr. David Onion
- Kaluza Composites Tutorial with Dr. David Onion
- Kaluza Cytobank Plugin
- Kaluza Linked Gates Tutorial with Dr. David Onion
- Kaluza Levey-Jennings Plots and Quality Control Analysis Tutorial with Dr. David Onion
- Kaluza Radar and Tree Plots Tutorial with Dr. David Onion
- Off-the-shelf, Echo-based DNA Assembly Automation presented by George McArthur, Arzeda @SLAS2020
- Optima AUC Cell Assembly Tutorial
- Optima AUC Cell Loading Tutorial
- Optima AUC Cell Preparation Tutorial
- Seminar: Diverse Applications of Flow Cytometry to Answer Biological Questions
- Extended Features for Kaluza Software Tutorial
- Getting to Know Kaluza Acquisition Software Tutorial
- Seminar: High Dimensional Flow Cytometry on Small Instrument Platforms Tutorial
- Kaluza Analysis Overview Tutorial
- Kaluza for Gallios Compensation Worklist Tutorial
- Kaluza for Gallios Simulator with a Legacy Browser Tutorial
- Kaluza for Gallios Software Tutorial - Flow Cytometry
- Kaluza Analysis Software Tutorial - Loading Files and Creating Plots
- Kaluza Analysis Software: Creating Overlay Plots
- Setting up Statistics with Kaluza Software Tutorial
- How to Fill and Seal a Quick-Seal Tube
- How to Seal Quick-Seal Tubes using the Cordless Tube Topper
- How to Use Open-Top Tubes in Ultracentrifuges
- How to Fill and Plug a OptiSeal Tube
- Syringe Extraction of a Ultra-Clear, Quick-Seal Tube
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Webinars
- Addressing the Challenges of Purification & Quality Control in Gene Therapy
- Cell-Free Technology and Acoustic Liquid Handling Are Helping Tierra Disrupt Natural Product Discovery
- Characterizing Viruses: From Deadly Pathogens to the Workhorses of Gene Therapy
- Cytobank Webinar - CITRUS in Practice with Dr. Anna Belkina
- Clinical Flow Cytometry User Group Meeting
- Kaluza Batch Analysis Tutorial with Dr. David Onion
- Webinar: Kaluza Software for Flow Cytometry Data Analysis
- Leveraging acoustic and tip-based liquid handling to increase SARS-CoV-2 sequencing throughput
- 17 Color Immunophenotyping using CytoFLEX LX and ViaKrome
- GMP Cleanroom Routine Environmental Monitoring & 21 CFR Part 11 Data Integrity
- 21 CFR Part 11 Data Integrity for Online TOC Instruments
- ACFTD Discontinuance and the HIAC 8011+ and HIAC PODS+
- Achieving Cell-Free Gene Expression with An Acoustic Liquid Handler
- Seminar: Advanced Sensitivity and Resolution in Flow Cytometry through Innovation
- Advances in Sedimentation Analysis by Dr. Borries Demeler
- Agencourt AMPure XP
- Automated Alternative to the Hanging Drop Method of Stem Cell Differentiation
- An End-to-End Automated Workflow for High-Throughput SARS-Cov-2 Sequencing and Surveillance
- Webinar: An Intro to Characterization of Biomolecules Using AUC
- Analysis of Cell Biochemical Processes from First Principles to Cytometry
- Analysis of Particle Size Distributions by Analytical Ultracentrifugation
- Analytical Ultracentrifugation For Structural Analysis - Proteins and Macromolecular Complexes
- Analytical Ultracentrifugation in the Biopharmaceutical Industry
- Analytical Ultracentrifugation in Nanoparticle Analysis
- Analytical Methods to Measure Empty and Full AAV Particles
- Analytical Ultracentrifugation of Carbon Nanotubes
- Applications of Counterflow Centrifugal Elutriation CCE
- Automated 3D Cell Culture and Screening by Imaging and Flow Cytometry
- Automated Assays For Protein Engineering, In Vitro And In Vivo, By Dr. Daniela Quaglia
- Automated High-Throughput and High-Content Analysis by Flow Cytometry
- Using Data to Drive Automated Screening and Effective Reporting
- Automating Continuous Cell Culture by Dr. Oliver Gassmann
- Taking the Tricky Out of Automating NGS Sample Prep
- Automation of PCR Setup and AMPure XP Purification using the Biomek 4000 Workstation
- Automation-Enabled LC-MS Analysis of Biologics
- Avoid Pitfalls When Automating Cell Viability Counting for Biopharmaceutical Quality Control
- Avoiding the Perils of Hidden Requirements
- Basic Research Signaling Applications
- B-cell Lymphoproliferative Disorders Diagnostics by Flow Cytometry
- The Use of the Analytical Ultracentrifuge to Characterize Very Large Complex Biopharmaceuticals
- Cell Counting & Viability: Faster Results Through Automation
- Cell Cycle Analysis by Quantitative Imaging Cytometry
- Cellular Analysis Using the Coulter Principle
- Centrifugal Elutriation - Utility in the Flow Cytometry Laboratory
- Centrifugation Safety 1 (Japanese)
- Centrifugation Safety 2
- Centrifugation Safety (Japanese)
- Changes to USP <1788>: Determination of Subvisible Particle Matter from the HIAC and Coulter Counters
- Changes to USP <643> Total Organic Carbon for Pharmaceutical Grade Waters
- Characterization of CRISPR Technologies Using Cell-Free Transcription and Translation and an Acoustic Liquid Handler
- Characterization of CRISPR Technologies Using Cell-Free Transcription and Translation and an Acoustic Liquid Handler
- Characterization of Extracellular Vesicles with Nanoscale Flow Cytometry
- Characterization of LNPs via Density Matching AUC
- Characterizing Viral Vector Fullness in Density Gradient Separations
- Choosing the Right TOC Analyzer for a Pharmaceutical QC Laboratory
- Cleanroom Routine Environmental Monitoring & Classification
- Contamination Control in the Hydraulic Industry
- Cytobank Bootcamp Session #6 Single Cell Data
- Cytobank Bootcamp Session #4 FlowSOM
- Cytobank Bootcamp Session #1 Introduction to Cytobank
- Cytobank Bootcamp Session #3 viSNE
- Cytobank Bootcamp Session #2 Data Management
- Cytobank Bootcamp Session #5 Biomarker discovery with CITRUS
- Machine Learning Assisted Population Identification
- Cytometry data sharing platform for collaborative multi-centric data analysis
- Data Insights for Automated Liquid Handling
- Dendritic Cells Sorting
- Detection of Microparticles with Flow Cytometry
- Diamond-Based Nanomedicine for Enhanced Cancer Treatment and Imaging
- Direct EV Measurement in Complex Biofluids Using Single Vesicle Flow Cytometry (vFC) and the CytoFLEX
- Recent Advances in Immunotherapy: Directing Cells to Address Disease
- Diversity of Cancer-Derived Extracellular Vesicles
- Diversity of Extracellular Vesicles and Their Cargo in Cell-To-Cell Communication
- DNA Cytometry with Kaluza
- Webinar: Flow Cytometry for Drug Allergy Diagnostics
- Emitting Dye for Violet Laser Excitation with Krome Orange
- Environmental Cleanroom Monitoring & 21 CFR Part 11 Data Integrity
- European Pharmacopoeia EP2.2.44 Total Organic Carbon
- Evolution in the Manufacturing of Cellular Therapies
- Exosome Biogenesis and the Budding of Proteins and Viruses
- High-Performance Exosome Purification and Characterization via automated Density Gradient
- Exploring Exosomes and the Tumor Microenvironment
- Exploring the Stoichiometry of Macromolecular Complexes Using Multi-Signal Sedimentation Velocity Analytical Ultracentrifugation
- Extracellular Vesicle Isolation by Flow Cytometric Sorting and Characterization by Analytical Ultra-Centrifugation and Dynamic Light Scatter
- Extracellular Vesicles Delivery and RNA Translation
- Fast Cost-Effective High Throughput Solutions for DNA Assembly
- Advanced Flow Cytometric Analysis of Human T-Cell Memory Subsets
- Flow Cytometry Data Analysis in a Flash
- Flow Cytometry in Clinical Immunology-Actual Approach to Immune Status Evaluation
- Fully Automated RNA Library Preparation for Sequencing Respiratory Viruses
- Gallios Flow Cytometer Forward Angle Light Scatter Innovation
- Goldilocks & the Three Cells: The Art of Monitoring & Managing Cell Cultures
- Hematopoietic Bone Marrow Cell Sorting without Compromise
- How Stem Cells Speak with Immune Cells
- ICH Q2 Validating a TOC Analyser with the QbD1200
- ICH Q2 Validation of Analytical Procedures for Pharmaceutical TOC Analyzers
- ICH Q2 Validation of On-line TOC Analyzers
- Identifying and Isolating Stem Cells Through High-Speed Cell Sorting
- Is Immunotherapy Living up to its Promise?
- New Strategies to Improve Your CE-SDS Results: A Data-driven Perspective
- New Automation Strategies For Improving Sample Prep - The Analytical Laboratory
- Initial Evaluation of the ClearLLab 10C System in the Immunophenotyping of Leukemia and Non Hodgkin Lymphoma
- Isolation and Characterization of Exosomes and Ectosomes
- Isolation of Extracellular Vesicles: Latest Advances and Challenges
- Large Scale Purification of RNA and RNA-based Nanoparticles by Preparative Ultracentrifugation
- Laser Cytometry in Biomedical Analysis
- Webinar: Leukocytes Immunophenotyping in COVID-19 Patients
- Leveraging the Value of Automated High-Content Screening
- Looking Under the Hood: Getting Started with the Optima AUC
- Cleanrooms: Controlling Contamination, Setting Alerts & Actions, Considerations of Removal Efficiency
- GMP Cleanroom Routine Environmental Monitoring & 21 CFR Part 11 Data Integrity
- Particle Monitoring Systems for Isolator / RABS Filling Lines and 503B Compounding Facilities
- Measuring Molecular Interactions by Multi-Wavelength AUC
- Microvesicle Detection and Cell Sorting
- On the Importance of Monitoring Both Transfection and Transduction Efficiencies in Cell Therapy Development
- Monitoring Signal Transduction Pathways in Human Disease
- Multicolor Flow Cytometry Webinar
- Multi-Color Solution for Flow Cytometry
- Combined Use of Multiple Particle Characterization Technologies to Evaluate Targeted Liposomal Formulations
- Multi-Sizing your Multi-Color for Panel Design
- Nano-Emulsion Formulation and Characterization Life Science and Industrial Markets
- Webinar: NanoGBS—A Miniaturized Procedure for Genotyping by Sequencing Library Preparation
- Next Generation Polymer Dyes: Enhance your multicolor flow cytometry panels
- Optimizing Quality Control Electronic Records for 21 CFR Part 11 Compliance
- Advanced Process Quality Control and Outlier Detection with Discrete Particle Analysis
- Overcoming the Hurdles of Density Gradient Ultracentrifugation for Optimized Gene Therapy Purification Workflows
- Particle Counters Must Now be Calibrated With ISO 21501-4
- Particle Size Analysis with Laser Diffraction and Result Interpretation
- Particle Size and Associated Sedimentary Processes on Wetland Gain and Loss in the Mississippi River Delta
- Particle Size Characterization by Laser Diffraction Analysis in Geoscience and Soil Science
- Particle Size Distribution for Cement using Laser Diffraction
- Q&A Panel discussion, LSUG Lab and Pharma Water speakers
- Total Organic Carbon Analysis in the new ASTM E3106 Cleaning Standard
- Real-Time Detection of Bioburden & Biofilm in Water Systems
- Pharmaceutical Water Production, Richard Jarrett, Evoqua Water Technologies
- Meeting Global TOC and Conductivity Pharmacopeia Compliance while using ALCOA Requirements to Protect Data Integrity
- Validation of Growth Direct to Perform Pharmaceutical Water Bioburden Analysis
- Physical and Chemical Characterization of Nanoparticle Constructs Using the Analytical Ultracentrifuge
- Plant Cell Cytometry Analysis
- Webinar: Practical aspects of laser diffraction results interpretation
- Predictive power of CITRUS
- Proteome Profiling of the Tumor Microenvironment: Role of Human Primary Fibroblasts Derived Exosomes in Oral Cancer Progression
- Quantifying Protein Aggregates by Sedimentation Velocity
- Quantitative Determination of Reaction Stoichiometry, Interaction Energies, and Solute Masses Using Analytical Ultracentrifugation
- Rare Event Analysis by Flow Cytometry
- Reducing Human Errors in Pharmaceutical Manufacturing Quality Control
- Rethinking Data Analysis for Flow Cytometry with Kaluza 1.1 Software
- The Revised ISO 14644-1 Changes Classification and Monitoring Methods
- Sample Prep for MS
- Changes in T- and B-lymphocytes after COVID-19 and SARS-CoV-2 specific immunity
- Scaling-Up Exosomes and Other Extracellular Vesicles
- Contemporary Cell Staining and Imaging Tools for Screening Stem Cell-Derived Cardiomyocytes
- Introduction to the New USP <787>: Subvisible Particulate Matter in Therapeutic Protein Injections
- Take the Risk out of Rotations Understanding and Implementing BioSafety Solutions in Centrifugation
- Testing Vaccines Final Form Dose to USP<787> Subvisible Particulate Matter
- The Art of Sorting for Advancing Cytometry
- The Complexities of SV Analytical Ultracentrifugation: AAVs are not Simple, Binary Systems
- The Future of Liquid Handling Automation has Arrived
- The Power of Automated Assay Optimization
- The Role of Exosomes in Inflammatory Disease - Pathogenesis and Treatment
- The Science of Flow Cytometry Part 1
- The Science of Flow Cytometry Part 2
- Three Distinct Analytical Ultracentrifugation Methods for Virus and Viral Vector Characterizations
- Transferring Cell Counting Methods: Best Practices
- Cross-talk and Developmental Programs - A Key to Translational Stem Cell Biology
- Understanding the How and the Why: Biosafety in Centrifugation
- Understanding the Role and Benefits of Centrifugation in Cell Harvest and Separation
- qPCR Webinar: Scalable Workflows for Viral RNA Extraction and Reaction Setup
- Development and Production of Viral Vectors: Advances in Processes and Translation for Human Gene Therapy
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Product Videos
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Product Applications
- Use of Cells in Therapeutics Product Development
- Lead Optimization
- Quality Control for GMP Manufacturing
- Echo Liquid Handling for ADME-Tox
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Biologics Product Applications
- High-Throughput Screen (HTS)
- Liquid Handling for Gene Expression
- Liquid Handling for Genotyping
- Helping the Immune System Beat Cancer: Biologics in Immuno-oncology Research
- Liquid Handling for Microbial Research
- A Natural Answer: Biologics 101
- Natural Factories: Biologics Production 101
- Package Delivery: Biologics as Vectors
- Acoustic Liquid Handling for Protein Crystallography
- PCR, qPCR, and RT-qPCR
- Restoring Balance: Biologics in Immune-Disorder Research
- Liquid Handling for Single-Cell Genomics
- Enabling COVID-19 Research
- Echo Liquid Handling for Microsampling
- Process Development Manufacturing: Biotherapeutics
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Techniques and Methods
- Cell Harvest
- Cytometrydotcom
- Cell Maintenance
- Immune Monitoring
- Interaction Quantification & Characterization Using Analytical Ultracentrifugation
- High-Throughput Screening
- Viral Particle Purification Using Centrifugation Methods
- Mass Spectrometry
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spINSIGHTS
- What’s the difference between sterile & Certified Free consumables, and what purity grade do I need?
- Why should I choose ultracentrifugation as the preferred method for extracellular vesicle purification?
- When should I choose centrifugation instead of affinity chromatography for purifying viral vectors?
- How can I develop a deeper understanding of my lipid nanoparticle heterogeneity?
- ELEVATING EV Characterization with Analytical Ultracentrifugation (AUC)
- What advantages does the Optima AUC provide to improve my data quality and workflow efficiency?
- How can I transfer an existing centrifugation protocol to a new rotor, bottle, or tube?
- Why should I use analytical ultracentrifugation (AUC) instead of other methods for AAV characterization?
- How can I prepare consistent density gradients for reproducibly purifying samples via ultracentrifugation?
- Can Sapphire windows be used for low-UV AUC experiments?
- An introduction to the Optima Analytical Ultracentrifuge
- How does data from AUC determine dose optimization in therapeutic liposomes?
- How can data from AUC help improve AAV Production Yield?
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Immunophenotyping
- About Immunophenotyping
- About Immunophenotyping
- Seven Tips for Achieving the Perfect Panel for Multicolor Flow Cytometry
- Seven Tips for Achieving the Perfect Panel for Multicolor Flow Cytometry
- Speed up your setup: The CytoFLEX Platform and how to fast-track 20-color panel design
- Free Fluorochrome chart for easy panel design
- Panel Builder
- Panel Builder Resources
- Instruments and Products for Immunophenotyping Assays
- Optimized Multicolor Immunophenotyping Panels (OMIPs) for Flow Cytometry
- Customer Testimonials
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Research Areas
- 3D Cell Culture
- Extracellular Vesicles
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HIV Advanced Disease Management
- 12 Steps to CD4 Testing
- Advanced Disease Management
- World Health Organization Guidelines Reinforce Role of CD4 Cell Counting in Immunocompromised Patients
- CD4 Testing in Remote Areas
- Innovation In CD4 Testing
- The Impact of Laboratory Proficiency Testing And External Quality Assurance Schemes In Resource Limited Settings
- What is CD4 & Why is it Important?
- An Overview of the Current Status for the Global HIV/AIDS Pandemic
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Small Particle
- Verifying for Small Particle with Certified Beads
- Instruments and Products for Biological Nanoparticles
- Characterization of Extracellular Vesicles with Nanoscale Flow Cytometry
- Measuring Single EVs and their Cargo: Sensitive and Specific Vesicle Flow Cytometry (vFCTM)
- Things to Consider for Small Particle Research
- Western Blot and Other Methods vs. Nanoscale Flow Cytometry
- About Biological Nanoparticles and Microparticles
- Easy to Learn: A New User CytoFLEX Experience
- A Discovery in the Williams Lab
- Trends in Extracellular Vesicle Research
- Free Extracellular Vesicles Poster For Your Lab
- Nanoscale Frequently Asked Questions
- Small Talk
- Karan's Story
- Astrios and the Nanoscale
- Cell Sorting at the Nano Scale
- The Importance of Guidelines in Small Particle Research
- How the CytoFLEX Enabled The Williams' Lab Extracellular Vesicles Research
- Machine Learning Assisted Analysis for Cytometry Data
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Applied Science
Related Video: Cellular Analysis Using the Coulter Principle