CD18 Antigen

The beta2 integrins (CD11/CD18) are the major adhesion molecule family of leukocytes. Most leukocytes express one or more members of this family. CD18 is the 95 kDa integrin β2-chain which forms non-covalently-bound heterodimers with one of four α subunits. The four alpha subunits are: CD11a (αL) (all leukocytes), CD11b (αM) (granulocytes, monocytes, some macrophages), CD11c (αX) (granulocytes, monocytes, dendritic antigen presenting cells), CD11d  (αD) (CD8 T-cell subpopulation including large granular lymphocytes, macrophages and gamma-delta T cells in splenic red pulp). CD18 is expressed by all leukocytes (including histiocytes - macrophages, Langerhan's cells and dendritic cells) but no platelets. Macrophages and granulocytes express 10-fold more CD18 than do lymphocytes.


 Clone: 7E4  Isotype: IgG1 Mouse

7E4 is a blocking monoclonal antibody in cell adhesion assays.
 



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Product Line Specifications

Format Liquid
Specificity CD18
Form PE
Clone 7E4
Isotype IgG1 Mouse
Cross Reactivity Cynomolgus Monkey, Indian Rhesus, Hamadyras Baboon, Olive Baboon, Ovine, Bovine, Porcine, Equine, Canine, Feline, Mink, Llama
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced IM1570U

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


Technical Documents